Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice

Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice

Background and Aims: Non-alcoholic steatohepatitis (NASH) is a multisystem condition, involving the liver, adipose tissue, and immune system. Regulatory T (Treg) cells are a subset of T cells that exert an immune-controlling effect. Previously, a reduction of Treg cells in the visceral adipose tissu...

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Bibliographic Details
Main Authors: Mikhaïl A. Van Herck, Luisa Vonghia, Wilhelmus J. Kwanten, Thomas Vanwolleghem, Didier G. Ebo, Peter P. Michielsen, Joris G. De Man, Lucio Gama, Benedicte Y. De Winter, Sven M. Francque
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
non-alcoholic steatohepatitis
adipose tissue inflammation
adoptive cell transfer
regulatory T cells
T helper 1 cells
PPAR-γ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01711/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01711/full

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