Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson’s disease

Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson’s disease

The aggregation of aminoacyl transfer RNA synthetase complex-interacting multifunctional protein-2 (AIMP2) accelerates α-synuclein aggregation via direct interaction, leading to enhanced dopaminergic neurotoxicity in Parkinson’s disease (PD). Thus, it would be beneficial to prevent AIMP2 aggregation...

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Bibliographic Details
Main Authors: Jeong-Yong Shin, Bina Lee, Sangwoo Ham, Ji Hun Kim, Hyojung Kim, Heejeong Kim, Min Gi Jo, Hye Jung Kim, Sang Won Park, Hee-Seok Kweon, Yong Jun Kim, Seung Pil Yun, Yunjong Lee
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
AIMP2 aggregates
α-synucleinopathy
AIMP2 inhibitors
Human dopaminergic neuron
Parkinson’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222012975

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http://www.sciencedirect.com/science/article/pii/S0753332222012975

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