Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole

Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole

Given our previous finding that fluorination at the C18 position of largazole showed reasonably good tolerance towards inhibitory activity and selectivity of histone deacetylases (HDACs), further modification on the valine residue in the fluoro-largazole’s macrocyclic moiety with S-Me <span style...

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Bibliographic Details
Main Authors: Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui, Xinsheng Lei
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Marine Drugs
Subjects:
marine natural product
largazole
HDAC inhibitors
modification
fluoro olefin
Online Access:https://www.mdpi.com/1660-3397/18/7/344

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https://www.mdpi.com/1660-3397/18/7/344

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