Detection and quantification of integrated vector copy number by multiplex droplet digital PCR in dual-transduced CAR T cells

Detection and quantification of integrated vector copy number by multiplex droplet digital PCR in dual-transduced CAR T cells

The success of chimeric antigen receptor (CAR) T cell therapies in refractory hematologic malignancies has prompted investigation of their efficacy in solid tumors. AUTO6NG is a dual-transduced GD2-targeting CAR that encodes distinct modules designed to enhance T cell activity in relapsed/refractory...

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Bibliographic Details
Main Authors: Wei Wang, Muhammad Al-Hajj, Alireza S. Alavi
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
droplet digital PCR
vector copy number
chimeric antigen receptor T cells
genetically engineered T cells
immunotherapy
cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001055

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http://www.sciencedirect.com/science/article/pii/S2329050123001055

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