Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells, and molecular mimicry between foreign and self...

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Bibliographic Details
Main Authors: Bernhard Loll, Christine Rückert, Barbara Uchanska-Ziegler, Andreas Ziegler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
HLA-B27
X-ray structure
peptide binding modes
conformational flexibility
T cell selection
central tolerance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00179/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00179/full

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