Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

Variations in tumor biology from patient to patient combined with the low overall survival rate of hepatocellular carcinoma (HCC) present significant clinical challenges. During the progression of chronic liver diseases from inflammation to the development of HCC, microenvironmental properties, incl...

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Bibliographic Details
Main Authors: Alican Özkan, Danielle L. Stolley, Erik N. K. Cressman, Matthew McMillin, Sharon DeMorrow, Thomas E. Yankeelov, Marissa Nichole Rylander
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
cirrhosis
desmoplasia
chemoresistance
hypoxia
3D cell culture
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.662135/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.662135/full

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