Berberine Suppresses Lung Metastasis of Cancer via Inhibiting Endothelial Transforming Growth Factor Beta Receptor 1

Berberine Suppresses Lung Metastasis of Cancer via Inhibiting Endothelial Transforming Growth Factor Beta Receptor 1

This study investigated the effects of berberine (BBR) on pancreatic cancer (PC) lung metastasis and explored the underlying mechanisms, using a BALB/C-nu/nu nude mouse model injected with PC cells (AsPC-1). Intragastric administration of BBR dose-dependently improves survival of mice intravenously...

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Bibliographic Details
Main Authors: Wenjia Tian, Huifeng Hao, Ming Chu, Jingjing Gong, Wenzhe Li, Yuan Fang, Jindong Zhang, Cunzheng Zhang, Yonghui Huang, Fei Pei, Liping Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
berberine
trans-endothelial migration
metastasis
TGFBR1
pancreatic cancer
endothelial barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.917827/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.917827/full

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