Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

APE1 plays an important role in the cellular response to oxidative stress, and mutations are linked to tumor progression and chemoresistance. Here, the authors characterize the interactions of APE1 with RNA and demonstrate a role in microRNA processing.

Bibliographic Details
Main Authors: Giulia Antoniali, Fabrizio Serra, Lisa Lirussi, Mikiei Tanaka, Chiara D’Ambrosio, Shiheng Zhang, Slobodanka Radovic, Emiliano Dalla, Yari Ciani, Andrea Scaloni, Mengxia Li, Silvano Piazza, Gianluca Tell
Format: Article
Language:English
Published: Nature Portfolio 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00842-8

Internet

https://doi.org/10.1038/s41467-017-00842-8

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