Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway

Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway

Acute liver injury (ALI) is a disease that seriously threatens human health and life, and a dysregulated inflammation response is one of the main mechanisms of ALI induced by various factors. Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein with multiple biological functions....

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Bibliographic Details
Main Authors: Xiao-qin Qu, Qiong-feng Chen, Qiao-qing Shi, Qian-qian Luo, Shuang-yan Zheng, Yan-hong Li, Liang-yu Bai, Shuai Gan, Xiao-yan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
PEBP4
acute liver injury
TLR4
NF-κB
inflammation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.901566/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.901566/full

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