Differential effects of human L1CAM mutations on complementing guidance and synaptic defects in Drosophila melanogaster.

A large number of different pathological L1CAM mutations have been identified that result in a broad spectrum of neurological and non-neurological phenotypes. While many of these mutations have been characterized for their effects on homophilic and heterophilic interactions, as well as expression le...

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Bibliographic Details
Main Authors: Sirisha Kudumala, Julie Freund, Michael Hortsch, Tanja A Godenschwege
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3796554?pdf=render