KUS121 attenuates the progression of monosodium iodoacetate-induced osteoarthritis in rats

Abstract Currently there is no effective treatment available for osteoarthritis (OA). We have recently developed Kyoto University Substances (KUSs), ATPase inhibitors specific for valosin-containing protein (VCP), as a novel class of medicine for cellular protection. KUSs suppressed intracellular AT...

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Bibliographic Details
Main Authors: Sachiko Iwai, Hanako O. Ikeda, Hisashi Mera, Kohei Nishitani, Motoo Saito, Akitaka Tsujikawa, Akira Kakizuka
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-95173-6