Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents

Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents

Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient and selective anticancer agents whose underlying mechanisms of action have been widely investigated. The introduction of N-bearing heterocycles (e.g., triazoles) into the structures of natural compounds (particula...

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Bibliographic Details
Main Authors: Marius Mioc, Alexandra Mioc, Alexandra Prodea, Andreea Milan, Mihaela Balan-Porcarasu, Roxana Racoviceanu, Roxana Ghiulai, Gheorghe Iovanescu, Ioana Macasoi, George Draghici, Cristina Dehelean, Codruta Soica
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
triterpenic acids
1-hydroxybenzotriazole esters
melanoma
cytotoxicity
rtPCR
apoptosis
Online Access:https://www.mdpi.com/1422-0067/23/17/9992

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https://www.mdpi.com/1422-0067/23/17/9992

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