Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival.

NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200 million people worldwide, maintain NAD homeostasis via th...

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Bibliographic Details
Main Authors: Michael D Schultz, Tulin Dadali, Sylvain A Jacques, Hélène Muller-Steffner, Jeremy B Foote, Leonardo Sorci, Esther Kellenberger, Davide Botta, Frances E Lund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008539

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https://doi.org/10.1371/journal.ppat.1008539

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