Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor

Meprin α is a proteolytic regulator of the extracellular matrix that forms enormous oligomeric filaments of unknown purpose. Here, the authors determine by cryo-EM the structural basis of the meprin supercoiled filament and further characterise a small molecule inhibitor bound to its active site.

Bibliographic Details
Main Authors: Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33893-7

Internet

https://doi.org/10.1038/s41467-022-33893-7

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