Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors

Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors

Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP). We investigated this interaction in HEK293 cells using carbachol and parathyroid hormone (PTH) to stimulate formation of IP3 and cAMP, respectiv...

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Bibliographic Details
Main Authors: Vera Konieczny, Stephen C. Tovey, Stefania Mataragka, David L. Prole, Colin W. Taylor
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
cyclic AMP
endoplasmic reticulum
inositol 1,4,5-trisphosphate
intracellular Ca2+ store
IRBIT
Golgi apparatus
parathyroid hormone
phospholipase C
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631765X

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http://www.sciencedirect.com/science/article/pii/S221112471631765X

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