Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors
Inositol 1,4,5-trisphosphate (IP3) stimulates Ca2+ release from the endoplasmic reticulum (ER), and the response is potentiated by 3′,5′-cyclic AMP (cAMP). We investigated this interaction in HEK293 cells using carbachol and parathyroid hormone (PTH) to stimulate formation of IP3 and cAMP, respectiv...
Main Authors: | Vera Konieczny, Stephen C. Tovey, Stefania Mataragka, David L. Prole, Colin W. Taylor |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-01-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471631765X |
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