Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs

Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs

The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an attractive therapeutic target for inflammatory br...

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Bibliographic Details
Main Authors: Carolina Pinto-Espinoza, Charlotte Guillou, Björn Rissiek, Maximilian Wilmes, Ehsan Javidi, Nicole Schwarz, Marten Junge, Friedrich Haag, Nastassia Liaukouskaya, Nicola Wanner, Annette Nicke, Catelijne Stortelers, Yossan-Var Tan, Sahil Adriouch, Tim Magnus, Friedrich Koch-Nolte
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
P2X7 nanobodies
receptor occupancy
functional blockade
intracerebroventricular delivery
AAV-mediated delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1029236/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1029236/full

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