Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs

Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs

The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an attractive therapeutic target for inflammatory br...

Full description

Bibliographic Details
Main Authors:	Carolina Pinto-Espinoza, Charlotte Guillou, Björn Rissiek, Maximilian Wilmes, Ehsan Javidi, Nicole Schwarz, Marten Junge, Friedrich Haag, Nastassia Liaukouskaya, Nicola Wanner, Annette Nicke, Catelijne Stortelers, Yossan-Var Tan, Sahil Adriouch, Tim Magnus, Friedrich Koch-Nolte
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Pharmacology
Subjects:	P2X7 nanobodies receptor occupancy functional blockade intracerebroventricular delivery AAV-mediated delivery
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1029236/full

Similar Items

Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
by: Maximilian Wilmes, et al.
Published: (2022-10-01)

A method for intracerebroventricular cannulation of young broiler chicks
by: Chris Lamberigts, et al.
Published: (2022-01-01)

Current Approaches and Future Perspectives for Nanobodies in Stroke Diagnostic and Therapy
by: Larissa Jank, et al.
Published: (2019-01-01)

Intracerebroventricular Ghrelin Administration Increases Depressive-Like Behavior in Male Juvenile Rats
by: Thomas M. Jackson, et al.
Published: (2019-04-01)

Intracerebroventricular Injection of Ghrelin Induces Sleep-Like Behavior in Neonatal Chicks
by: Tetsuya Tachibana, et al.
Published: (2001-10-01)

Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice
by: Catalina Abad, et al.
Published: (2024-01-01)

Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity
by: Stephan Menzel, et al.
Published: (2018-03-01)

Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies
by: Mohadeseh Haji Abdolvahab, et al.
Published: (2024-02-01)

Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats
by: Xiao-Bo Huang, et al.
Published: (2018-01-01)

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice
by: Mika Aoyagi-Scharber, et al.
Published: (2017-09-01)

Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease
by: Simone Rolfes, et al.
Published: (2020-10-01)

Beta-Amyloid and Its Asp7 Isoform: Morphological and Aggregation Properties and Effects of Intracerebroventricular Administration
by: Valeriya Ushakova, et al.
Published: (2024-10-01)

Study the Antinociceptive Effect of Intracerebroventricular Injection of Aqueous Extract of Origanum Vulgare Leaves in Rat: Possible Involvement of Opioid System
by: Yasaman Pahlavan, et al.
Published: (2013-10-01)

Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys
by: Jason Pinkstaff, et al.
Published: (2023-01-01)

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery
by: Tin Chanh Pham, et al.
Published: (2021-02-01)

Intracerebroventricular Administration of Interferon-Alpha Induced Depressive-Like Behaviors and Neurotransmitter Changes in Rhesus Monkeys
by: Zhifei Li, et al.
Published: (2020-11-01)

Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy
by: Sun S, et al.
Published: (2021-03-01)

Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano)
by: Mélanie Demeules, et al.
Published: (2020-09-01)

Nanobodies as modulators of inflammation: potential applications for acute brain injury
by: Björn eRissiek, et al.
Published: (2014-10-01)

Intracerebroventricular Injection of L-Alanine Induces a Sedative Effect under an Acute Stressful Condition in Neonatal Chicks
by: Isao Kurauchi, et al.
Published: (2006-11-01)

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics
by: Peter Bannas, et al.
Published: (2017-11-01)

Intracerebroventricular Administration of Growth Hormone Releasing Peptide-6 (GHRP-6) Inhibits Food Intake, but not Food Retention of Crop and Stomach in Neonatal Chicks
by: Md. Sakirul Islam Khan, et al.
Published: (2006-02-01)

Generation and characterization of antagonistic anti-human CD39 nanobodies
by: Stephan Menzel, et al.
Published: (2024-03-01)

Sonication is a suitable method for loading nanobody into glioblastoma small extracellular vesicles
by: Sara Colja, et al.
Published: (2023-05-01)

ASC nanobodies to counteract the consequences of inflammasome activation
by: Sahil Adriouch, et al.
Published: (2022-05-01)

Treatment of Carbapenem-Resistant Multidrug-Resistant Gram-Negative Bacilli with Intracerebroventricular Injection of Polymyxin B: A Retrospective Study
by: Liu D, et al.
Published: (2022-12-01)

Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial
by: Hee Jin Kim, et al.
Published: (2021-09-01)

A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo
by: Henri Gondé, et al.
Published: (2021-08-01)

Nanobody-Based Delivery Systems for Diagnosis and Targeted Tumor Therapy
by: Yaozhong Hu, et al.
Published: (2017-11-01)

Intracerebroventricular Enzyme Replacement Therapy in Patients with Neuropathic Form of Mucopolysaccharidosis Type II: to Help Practicing Physician
by: Nataliya V. Zhurkova, et al.
Published: (2024-09-01)

Development of specific nanobodies (VHH) for CD19 immuno-targeting of human B-lymphocytes
by: Seyed Reza Banihahsemi, et al.
Published: (2018-05-01)

Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies
by: Evangelia Bolli, et al.
Published: (2021-05-01)

Efficacy of dual intracerebroventricular and intravitreal CLN5 gene therapy in sheep prompts the first clinical trial to treat CLN5 Batten disease
by: Samantha J. Murray, et al.
Published: (2023-10-01)

Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease
by: Nadia L. Mitchell, et al.
Published: (2023-08-01)

Cell-specific targeting by engineered M13 bacteriophage expressing VEGFR2 nanobody
by: Farideh Ranjibar, et al.
Published: (2018-09-01)

Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo
by: Mélanie Demeules, et al.
Published: (2022-10-01)

Lactic Acid Bacteria as a Live Delivery System for the in situ Production of Nanobodies in the Human Gastrointestinal Tract
by: Beatriz del Rio, et al.
Published: (2019-01-01)

Inadvertent administration of intravenous anaesthesia induction agents via the intracerebroventricular, neuraxial or peripheral nerve route – A narrative review
by: Santosh Patel
Published: (2024-01-01)

Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats
by: Yeh C, et al.
Published: (2016-10-01)

Intracerebroventricular Administration of Human Umbilical Cord Blood—Derived Mesenchymal Stem Cells Induces Transient Inflammation in a Transgenic Mouse Model and Patients with Alzheimer’s Disease
by: Su Hyeon Myeong, et al.
Published: (2022-02-01)