Abnormal Expression of Prolyl Oligopeptidase (POP) and Its Catalytic Products Ac-SDKP Contributes to the Ovarian Fibrosis Change in Polycystic Ovary Syndrome (PCOS) Mice

Abnormal Expression of Prolyl Oligopeptidase (POP) and Its Catalytic Products Ac-SDKP Contributes to the Ovarian Fibrosis Change in Polycystic Ovary Syndrome (PCOS) Mice

Polycystic ovary syndrome (PCOS) is an endocrine disorder and metabolic syndrome. Ovarian fibrosis pathological change in PCOS has gradually attracted people’s attention. In this study, we constructed a PCOS mouse model through the use of dehydroepiandrosterone. Sirius red staining showed that the o...

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Bibliographic Details
Main Authors: Suo Han, Shimeng Wang, Xiang Fan, Mengchi Chen, Xiaojie Wang, Yingtong Huang, Hongdan Zhang, Yinyin Ma, Jing Wang, Chunping Zhang
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
polycystic ovary syndrome (PCOS)
prolyl oligopeptidase (POP)
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP)
fibrosis
TGF-β1
MMP2
Online Access:https://www.mdpi.com/2227-9059/11/7/1927

Internet

https://www.mdpi.com/2227-9059/11/7/1927

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