Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior and glucose homeostasis. Herein, the pharmacological profile of a homogenous...

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Bibliographic Details
Main Authors: Benjamin Lefranc, Karima Alim, Cindy Neveu, Olivier Le Marec, Christophe Dubessy, Jean A. Boutin, Julien Chuquet, David Vaudry, Gaëtan Prévost, Marie Picot, Hubert Vaudry, Nicolas Chartrel, Jérôme Leprince
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
GPR103
QRFP
RFamide
intracellular calcium concentration
peptide analog
Online Access:https://www.mdpi.com/1420-3049/26/14/4312

Internet

https://www.mdpi.com/1420-3049/26/14/4312

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