A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia?
The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in chronic myeloid leukemia (CML), but rarely found in ALL. We report here the case...
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| Language: | English |
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Sociedade Brasileira de Genética
2003-01-01
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300006 |
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| author | Mireille Guimarães Vaz de Campos Maria de Lourdes L. Ferrari Chauffaille Celso Arrais Rodrigues Everson A. Krum Mihoko Yamamoto |
| author_facet | Mireille Guimarães Vaz de Campos Maria de Lourdes L. Ferrari Chauffaille Celso Arrais Rodrigues Everson A. Krum Mihoko Yamamoto |
| author_sort | Mireille Guimarães Vaz de Campos |
| collection | DOAJ |
| description | The Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in chronic myeloid leukemia (CML), but rarely found in ALL. We report here the case of a girl diagnosed with ALL at 7 years of age. After treatment with the pediatric protocol BFM 83 for ALL, she stayed in continuous complete remission for nine years. At age 19, she was re-admitted with a white blood cell count of 6.8 x 10(9)/L with 3% blasts, and a platelet count of 65 x 109/L. Bone marrow aspirate showed 92.6% lymphoid blast cells, and chromosome analysis after G-banding revealed the karyotype 51,XX,+?5,t(9;22)(q34.1;q11.2),+16,+20,+21,+der(22)t(9;22)(q34.1;q11.2) [10]/46,XX[1]. FISH analysis for the BCR/ABL fusion showed 56% of interphase cells with two fusion signals, 30% with one, and 6% with three. Double Ph is rare in relapsed leukemia, and the possibility of secondary leukemia cannot be ruled out. |
| first_indexed | 2024-12-10T06:02:48Z |
| format | Article |
| id | doaj.art-3871648837a44991832689d2ff7dae0a |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-10T06:02:48Z |
| publishDate | 2003-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-3871648837a44991832689d2ff7dae0a2022-12-22T01:59:47ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852003-01-0126324925110.1590/S1415-47572003000300006A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia?Mireille Guimarães Vaz de CamposMaria de Lourdes L. Ferrari ChauffailleCelso Arrais RodriguesEverson A. KrumMihoko YamamotoThe Philadelphia chromosome is observed in 5% of pediatric acute lymphocytic leukemia (ALL) and in 25% to 50% of adult ALL cases, and is associated with poor prognosis. Double Ph in a hyperdiploid karyotype is common in chronic myeloid leukemia (CML), but rarely found in ALL. We report here the case of a girl diagnosed with ALL at 7 years of age. After treatment with the pediatric protocol BFM 83 for ALL, she stayed in continuous complete remission for nine years. At age 19, she was re-admitted with a white blood cell count of 6.8 x 10(9)/L with 3% blasts, and a platelet count of 65 x 109/L. Bone marrow aspirate showed 92.6% lymphoid blast cells, and chromosome analysis after G-banding revealed the karyotype 51,XX,+?5,t(9;22)(q34.1;q11.2),+16,+20,+21,+der(22)t(9;22)(q34.1;q11.2) [10]/46,XX[1]. FISH analysis for the BCR/ABL fusion showed 56% of interphase cells with two fusion signals, 30% with one, and 6% with three. Double Ph is rare in relapsed leukemia, and the possibility of secondary leukemia cannot be ruled out.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300006relapsed acute lymphocytic leukemiadouble Philadelphia chromosome |
| spellingShingle | Mireille Guimarães Vaz de Campos Maria de Lourdes L. Ferrari Chauffaille Celso Arrais Rodrigues Everson A. Krum Mihoko Yamamoto A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? Genetics and Molecular Biology relapsed acute lymphocytic leukemia double Philadelphia chromosome |
| title | A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? |
| title_full | A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? |
| title_fullStr | A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? |
| title_full_unstemmed | A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? |
| title_short | A rare case of Acute Lymphocytic Leukemia (ALL) presenting with double Philadelphia chromosome: relapse or secondary leukemia? |
| title_sort | rare case of acute lymphocytic leukemia all presenting with double philadelphia chromosome relapse or secondary leukemia |
| topic | relapsed acute lymphocytic leukemia double Philadelphia chromosome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300006 |
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