The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

ABSTRACT Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcription factor C4_02500C_A (Adr1) conferred significant resistance against fluconazole. In Sacc...

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Bibliographic Details
Main Authors: Manjari Shrivastava, Gaëlle S. Kouyoumdjian, Eftyhios Kirbizakis, Daniel Ruiz, Manon Henry, Antony T. Vincent, Adnane Sellam, Malcolm Whiteway
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
rewiring
Adr1
ergosterol
Candida albicans
alcohol and fatty acid metabolism
Online Access:https://journals.asm.org/doi/10.1128/mbio.01807-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01807-23

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