Metabolic Syndrome Induces Epigenetic Alterations in Mitochondria-Related Genes in Swine Mesenchymal Stem Cells

Metabolic Syndrome Induces Epigenetic Alterations in Mitochondria-Related Genes in Swine Mesenchymal Stem Cells

Autologous mesenchymal stem/stromal cells (MSCs) have demonstrated important therapeutic effects in several diseases. Cardiovascular risk factors may impair MSC mitochondrial structure and function, but the underlying mechanisms remain unknown. We hypothesized that metabolic syndrome (MetS) induces...

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Bibliographic Details
Main Authors: Kamalnath S. Rajagopalan, Sara Kazeminia, Logan M. Glasstetter, Rahele A. Farahani, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Alejandro R. Chade, Amir Lerman, Lilach O. Lerman, Alfonso Eirin
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
mesenchymal stem cells
metabolic syndrome
mitochondria
epigenetics
MeDIP-seq
DNA methylation
Online Access:https://www.mdpi.com/2073-4409/12/9/1274

Internet

https://www.mdpi.com/2073-4409/12/9/1274

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