Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Abstract Background RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic RABs in colorectal carcinogenesis remain to be elucidated. Methods Immun...

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Bibliographic Details
Main Authors: Yu-Chan Chang, Chia-Yi Su, Ming-Huang Chen, Wei-Shone Chen, Chi-Long Chen, Michael Hsiao
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Cancer
Subjects:
RAB GTPases
RAB3C
IL-6
STAT3
Colon cancer
Online Access:http://link.springer.com/article/10.1186/s12943-017-0687-7

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http://link.springer.com/article/10.1186/s12943-017-0687-7

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