Genetic Variants in the <i>FGB</i> and <i>FGG</i> Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype

Genetic Variants in the <i>FGB</i> and <i>FGG</i> Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype

Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (Aα, Bβ, and γ), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble polymer fibrin gives structural stability, strength, and adhesive surfaces for growing blood clots. Equally important,...

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Bibliographic Details
Main Authors: Tomas Simurda, Monika Brunclikova, Rosanna Asselta, Sonia Caccia, Jana Zolkova, Zuzana Kolkova, Dusan Loderer, Ingrid Skornova, Jan Hudecek, Zora Lasabova, Jan Stasko, Peter Kubisz
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
fibrinogen
quantitative fibrinogen disorders
beta and gamma nodules
<i>FGB</i> gene
<i>FGG</i> gene
mutations associated with thrombosis
Online Access:https://www.mdpi.com/1422-0067/21/13/4616

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https://www.mdpi.com/1422-0067/21/13/4616

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