An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

An optimized exosome production strategy for enhanced yield while without sacrificing cargo loading efficiency

Abstract Background Exosome mediated mRNA delivery is a promising strategy for the treatment of multiple diseases. However, the low yield of exosomes is a bottleneck for clinical translation. In this study, we boosted exosome production via simultaneously reducing the expression of genes inhibiting...

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Bibliographic Details
Main Authors: Rongxin Zhang, Te Bu, Ruidan Cao, Zhelong Li, Chen Wang, Bing Huang, Mengying Wei, Lijun Yuan, Guodong Yang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Nanobiotechnology
Subjects:
Exosomes
Yield
mRNA cargo
Red cell membrane
Familial hypercholesterolemia
Online Access:https://doi.org/10.1186/s12951-022-01668-3

Internet

https://doi.org/10.1186/s12951-022-01668-3

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