Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications

Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications

UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast and of UNC-51 in Caenorhabditis elegans. ULK1 is well-known for autophagy activation, which is evolutionarily conserved in protein t...

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Bibliographic Details
Main Authors: Ling Zou, Minru Liao, Yongqi Zhen, Shiou Zhu, Xiya Chen, Jin Zhang, Yue Hao, Bo Liu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
UNC-51-like kinase 1 (ULK1)
Autophagy
Non-autophagy
Biological function
Small-molecule drug
ULK1-targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522002702

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http://www.sciencedirect.com/science/article/pii/S2211383522002702

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