Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that targeting chromatin-modifying histone deacetylases may provide...

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Bibliographic Details
Main Authors: Tanya J. Applegate, Greta M. Krafsur, June A. Boon, Hui Zhang, Min Li, Timothy N. Holt, S. Kelly Ambler, Benjamin A. Abrams, Daniel L. Gustafson, Karsten Bartels, Franklyn B. Garry, Kurt R. Stenmark, R. Dale Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
pulmonary hypertension
epigenetics
histone deacetylases
vorinostat
echocardiography
bovine
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.712583/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.712583/full

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