Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium

Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium

Age-related macular degeneration (AMD) is a leading cause of vision loss among elderly people in developed countries. Neovascular AMD (nAMD) accounts for more than 90% of AMD-related vision loss. At present, intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is widely used...

Full description

Bibliographic Details
Main Authors: Dandan Liu, Chaoyang Zhang, Jingting Zhang, Guo-Tong Xu, Jingfa Zhang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Neurobiology of Disease
Subjects:
Neovascular AMD
Subretinal fibrosis
EMT
TGF-β signaling
Wnt signaling
Hedgehog signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002656

Internet

http://www.sciencedirect.com/science/article/pii/S0969996123002656

Similar Items