Novel fluorescent-based reporter cell line engineered for monitoring homologous recombination events.

Novel fluorescent-based reporter cell line engineered for monitoring homologous recombination events.

Homologous recombination (HR) faithfully restores DNA double-strand breaks. Defects in this HR repair pathway are associated with cancer predisposition. In genetic engineering, HR has been used extensively to study gene function and it represents an ideal method of gene therapy for single gene disor...

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Bibliographic Details
Main Authors: Alejandra Bernardi, Dino Gobelli, Julia Serna, Paulina Nawrocka, Gabriel March-Rosselló, Antonio Orduña, Piotr Kozlowski, María Simarro, Miguel A de la Fuente
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0237413&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0237413&type=printable

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