Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

RNAi by short hairpin RNA (shRNA) is a powerful tool not only for studying gene functions in various organisms, including mammals, but also for the treatment of severe disorders. However, shRNA-expressing vectors can induce type I interferon (IFN) expression by activation of innate immune responses,...

Full description

Bibliographic Details
Main Authors: Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Kosuke Takayama, Masashi Tachibana, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303754

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116303754

Similar Items