Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders

TAM receptors (TYRO3, AXL, and MERTK) comprise a family of homologous receptor tyrosine kinases (RTK) that are expressed across a range of liquid and solid tumors where they contribute to both oncogenic signaling to promote tumor proliferation and survival, as well as expressed on myeloid and immune...

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Bibliographic Details
Main Authors: Varsha Gadiyar, Gopi Patel, Jesse Chen, Dominico Vigil, Nan Ji, Veronica Campbell, Kirti Sharma, Yatao Shi, Matthew M. Weiss, Raymond B. Birge, Viralkumar Davra
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
TAM receptors
MERTK
AXL
TYRO3
receptor down-regulation
heterobifunctional targeted protein degraders
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135373/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135373/full

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