Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

Abstract Maternal overnutrition during lactation predisposes offspring to develop metabolic diseases and exacerbates the relevant syndromes in males more than females in later life. The hypothalamus is a heterogenous brain region that regulates energy balance. Here we combined metabolic trait quanti...

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Bibliographic Details
Main Authors: Yi Huang, Anyongqi Wang, Wenjiang Zhou, Baoguo Li, Linshan Zhang, Agata M. Rudolf, Zengguang Jin, Catherine Hambly, Guanlin Wang, John R. Speakman
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46589-x