Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction

Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction

Abstract Background Obesity has been identified as a risk factor for acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, the underlying mechanisms remain elusive. This study aimed to investigate the role of fatty acid synthase (FASN) in lipopolysaccharide (LPS)-induced ALI und...

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Bibliographic Details
Main Authors: Zhuhua Wu, Li Zhu, Xinran Nie, Yingli Liu, Xiaoju Zhang, Yong Qi
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Respiratory Research
Subjects:
Obesity
Fatty acid synthase
Acute lung injury
Endothelial cells
VE-cadherin
Online Access:https://doi.org/10.1186/s12931-023-02382-w

Internet

https://doi.org/10.1186/s12931-023-02382-w

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