Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus

Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NF-κB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus

Haemonchus contortus is an important parasitic nematode of ruminants. Previous studies showed that H. contortus escape the immunity through complex mechanisms, including releasing excretory/secretory proteins (ESPs) to modulate the host immune response. However, the detailed mechanism through which...

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Bibliographic Details
Main Authors: Zhaohai Wen, Yue Zhang, Jiajun Feng, Kalibixiati Aimulajiang, Muhammad Tahir Aleem, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Haemonchus contortus
HcESPs
PBMCs
TLR4/NF-κB/MAPKs signaling pathway
immune evasion
pattern recognition receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1013159/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1013159/full

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