Mechanism of Virus Attenuation by Codon Pair Deoptimization

Mechanism of Virus Attenuation by Codon Pair Deoptimization

Summary: Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that leads to attenuation is unknown. The strategy involves synthetic recoding of viral genomes that alters the positions of synonymous codons, thereby increasing the number of suboptimal codon pairs and...

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Bibliographic Details
Main Authors: Nicole Groenke, Jakob Trimpert, Sophie Merz, Andelé M. Conradie, Emanuel Wyler, Hongwei Zhang, Orsalia-Georgia Hazapis, Sebastian Rausch, Markus Landthaler, Nikolaus Osterrieder, Dusan Kunec
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305350

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http://www.sciencedirect.com/science/article/pii/S2211124720305350

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