Glutamatergic dysfunction in Schizophrenia

Abstract The NMDA-R hypofunction model of schizophrenia started with the clinical observation of the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or ketamine. Healthy volunteers exposed to acute low doses of ketamine experienced mild psychosis but also negative a...

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Bibliographic Details
Main Authors: Andreas O. Kruse, Juan R. Bustillo
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02253-w