Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages

Shikonin ameliorated mice colitis by inhibiting dimerization and tetramerization of PKM2 in macrophages

Dysregulated immune response plays a pivotal role in Ulcerative colitis. In lamina propria of inflammatory colonic mucosa, macrophages tend to polarize into M1 type and metabolically reprogram to aerobic glycolysis. PKM2 orchestrates glucose metabolic switch in macrophages, which tetramer has high p...

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Bibliographic Details
Main Authors: Baoyuan Huang, Qiumei Wang, Lin Jiang, Shuru Lu, Chengcheng Li, Chunqi Xu, Caiyan Wang, Enxin Zhang, Xiaojun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
shikonin
PKM2
polymer
ulcerative colitis
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.926945/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.926945/full

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