Early deficits in GABA inhibition parallels an increase in L-type Ca2+ currents in the jaw motor neurons of SOD1G93A mouse model for ALS

Early deficits in GABA inhibition parallels an increase in L-type Ca2+ currents in the jaw motor neurons of SOD1G93A mouse model for ALS

Amyotrophic Lateral Sclerosis (ALS) involves protracted pre-symptomatic periods of abnormal motor neuron (MN) excitability occurring in parallel with central and peripheral synaptic perturbations. Focusing on inhibitory control of MNs, we first compared longitudinal changes in pre-synaptic terminal...

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Bibliographic Details
Main Authors: Sharmila Venugopal, Zohal Ghulam-Jhelani, In Sook Ahn, Xia Yang, Martina Wiedau, Dwayne Simmons, Scott H. Chandler
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neurobiology of Disease
Subjects:
Motor neurons
SOD1G93A mouse
Tonic GABA
Neural homeostasis
Trigeminal
Oculomotor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000062

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http://www.sciencedirect.com/science/article/pii/S0969996123000062

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