PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis

PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis

We recently showed that melatonin ameliorates the severity of experimental autoimmune encephalomyelitis (EAE), an animal model of MS. However, efficiency of melatonin therapy was associated with side effects, manifested by slowing down of remyelination, through increasing the inhibitory effects of b...

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Bibliographic Details
Main Authors: Majid Ghareghani, Zahra Farhadi, Serge Rivest, Kazem Zibara
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
melatonin
diisopropylamine dichloroacetate
experimental autoimmune encephalomyelitis (EAE)
fatty acids
multiple scleorsis (MS)
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.862316/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.862316/full

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