Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

Abstract Background The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis. Methods Here, we use a mouse model that is deficient in Abi3 locus to study how the loss of function of Abi...

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Bibliographic Details
Main Authors: Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E. Golde, Paramita Chakrabarty
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Plaque burden
Neurofibrillary tangle
Disease signature
Risk factor
Gene dose
Online Access:https://doi.org/10.1186/s13195-022-01044-1

Internet

https://doi.org/10.1186/s13195-022-01044-1

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