Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

Enterococcus faecalis has been reported to inhibit Candida albicans virulence via secretion of the bacteriocin EntV. Here, the authors present the crystal structure and characterise the antifungal properties of this peptide in numerous in vitro and in vivo assays.

Bibliographic Details
Main Authors: Melissa R. Cruz, Shane Cristy, Shantanu Guha, Giuseppe Buda De Cesare, Elena Evdokimova, Hiram Sanchez, Dominika Borek, Pedro Miramón, Junko Yano, Paul L. Fidel, Alexei Savchenko, David R. Andes, Peter J. Stogios, Michael C. Lorenz, Danielle A. Garsin
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33613-1

Internet

https://doi.org/10.1038/s41467-022-33613-1

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