AM1638, a GPR40-Full Agonist, Inhibited Palmitate-Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner

AM1638, a GPR40-Full Agonist, Inhibited Palmitate-Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner

Background G protein-coupled receptor 40 (GPR40) is a key molecule in diabetes and fatty liver, but its role in endothelial dysfunction remains unclear. Our objective in this study was to determine whether GPR40 agonists protect endothelial cells against palmitatemediated oxidative stress. Methods H...

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Bibliographic Details
Main Authors: Hwan-Jin Hwang, Joo Won Kim, SukHwan Yun, Min Jeong Park, Eyun Song, Sooyeon Jang, Ahreum Jang, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
Format: Article
Language:English
Published: Korean Endocrine Society 2023-12-01
Series:Endocrinology and Metabolism
Subjects:
gpr40 agonist
human umbilical vein endothelial cell
nrf2
palmitates
endoplasmic reticulum stress
cytotoxicity
Online Access:http://www.e-enm.org/upload/pdf/enm-2023-1774.pdf

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http://www.e-enm.org/upload/pdf/enm-2023-1774.pdf

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