Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis

Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis

BackgroundUp to 80% of breast cancers (BCa) are estrogen receptor positive and current treatments target the estrogen receptor (endocrine therapies) and/or CDK4/6 (CDK4/6 inhibitors). CCND1 encodes the protein cyclin D1, responsible for regulation of G1 to S phase transition in the cell cycle. CCND1...

Full description

Bibliographic Details
Main Authors: Sarah A. Jeffreys, Therese M. Becker, Sarah Khan, Patsy Soon, Hans Neubauer, Paul de Souza, Branka Powter
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Endocrinology
Subjects:
breast cancer
CCND1
cyclin D1
biomarker
meta-analysis
systematic review
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.895729/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.895729/full

Similar Items