The pharmacokinetics of oral trazpiroben (TAK‐906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study

Abstract Trazpiroben is a dopamine D2/D3 receptor antagonist under development for the treatment of gastroparesis. This phase I, open‐label, randomized, two‐way crossover study (NCT04121078) evaluated the effect of single‐dose intravenous rifampin, a potent inhibitor of the organic anion transportin...

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Bibliographic Details
Main Authors: Jatinder K. Mukker, George Dukes, Max Tolkoff, Lisi Wang, Cristina Almansa, Susanna Y. Huh, Mitsuhiro Nishihara, Diane Ramsden, Chunlin Chen
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13274