Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge.

Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge.

Chikungunya virus (CHIKV) infection is characterized by rash, acute high fever, chills, headache, nausea, photophobia, vomiting, and severe polyarthralgia. There is evidence that arthralgia can persist for years and result in long-term discomfort. Neurologic disease with fatal outcome has been docum...

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Bibliographic Details
Main Authors: Petra van den Doel, Asisa Volz, Jouke M Roose, Varsha D Sewbalaksing, Gorben P Pijlman, Ingeborg van Middelkoop, Vincent Duiverman, Eva van de Wetering, Gerd Sutter, Albert D M E Osterhaus, Byron E E Martina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4154657?pdf=render

Internet

http://europepmc.org/articles/PMC4154657?pdf=render

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