TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development

TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development

Summary: Targeted deletion of TRAF7 revealed that it is a crucial part of shear stress-responsive MEKK3-MEK5-ERK5 signaling pathway induced in endothelial cells by blood flow. Similar to Mekk3-, Mek5- or Erk5-deficient mice, Traf7-deficient embryos died in utero around midgestation due to impaired e...

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Bibliographic Details
Main Authors: Erdyni N. Tsitsikov, Khanh P. Phan, Yufeng Liu, Alla V. Tsytsykova, Mike Kinter, Lauren Selland, Lori Garman, Courtney Griffin, Ian F. Dunn
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Molecular biology
Developmental biology
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015511

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http://www.sciencedirect.com/science/article/pii/S2589004223015511

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