Improvement of cancer immunotherapy by combining molecular targeted therapy

Improvement of cancer immunotherapy by combining molecular targeted therapy

In human cancer cells, a constitutive activation of MAPK, STAT3, β-catenin, and various other signaling pathways triggers multiple immunosuppressive cascades. These cascades result in the production of immunosuppressive molecules (e.g. TGF-β, IL-10, IL-6, VEGF, and CCL2) and induction of immunosuppr...

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Bibliographic Details
Main Authors: Yutaka eKawakami, Tomonori eYaguchi, Hidetoshi eSumimoto, Chie eKudo-Saito, Tomoko eIwata-Kajihara, Shoko eNakamura, Takahiro eTsujikawa, Jeong Hoon Park, Boryana K Popivanova, Junichiro eMiyazaki, Naoshi eKawamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Oncology
Subjects:
Immunosuppression
Immunotherapy
Tumor Microenvironment
NF-κB
MAPK
stat3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00136/full

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