Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes

Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes

Objective: Hyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM). Likewise, patients with genetic iron overload diseases develop diabetes, suggesting a tight link between iron metabolism and diabetes. The liver controls systemic iron homeo...

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Bibliographic Details
Main Authors: Ruiyue Qiu, Kristina Alikhanyan, Nadine Volk, Oriana Marques, Christina Mertens, Anand Ruban Agarvas, Sanjana Singh, Rainer Pepperkok, Sandro Altamura, Martina U. Muckenthaler
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
T2DM
Iron overload
Hepatocytes
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002137

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http://www.sciencedirect.com/science/article/pii/S2212877822002137

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