Dissection of affinity captured LINE-1 macromolecular complexes

Dissection of affinity captured LINE-1 macromolecular complexes

Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs). These RNPs interact with diverse host proteins, some repressive and others required for the L1 lifecycle. Using dif...

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Bibliographic Details
Main Authors: Martin S Taylor, Ilya Altukhov, Kelly R Molloy, Paolo Mita, Hua Jiang, Emily M Adney, Aleksandra Wudzinska, Sana Badri, Dmitry Ischenko, George Eng, Kathleen H Burns, David Fenyö, Brian T Chait, Dmitry Alexeev, Michael P Rout, Jef D Boeke, John LaCava
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
LINE-1
retrotransposon
ribonucleoprotein
interactome
affinity proteomics
biochemistry
Online Access:https://elifesciences.org/articles/30094

Internet

https://elifesciences.org/articles/30094

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